Veterinary API

As a Veterinary API manufacturer, Shanghai Moxi Biotechnology Co., Ltd. was established in 2015 and is headquartered in Jiading District, Shanghai, with its factory located in Yancheng, Jiangsu Province. We specialize in Veterinary API, Coccidiostat Series Products, Antibiotic Series Products R&D, production and sales. We have invested more than 10 million yuan to establish an advanced laboratory, covering technologies such as new bacterial strain construction, transformation and fermentation, product separation and purification. The R&D team consists of more than 20 people, has strong technological innovation capabilities, and is a domestic leader in multiple technical fields. The company adheres to the spirit of "pragmatism, hard work, and responsibility" and has established cooperative relationships with many universities and scientific research institutions. You can learn more about the following products, If you have any special needs, please feel free to contact us and we will provide you with professional pre-sales and after-sales services.

What Is Veterinary API ?

Veterinary API refers to a kind of substance or mixture in medicine manufacturing. The substance is the main active ingredients of medicine, which play a pharmacological role in the treatment and prevent of disease. It can directly have effects on the function or structure of the body and play curative role.

What are advantages of Veterinary API ?

Pure

Veterinary API pure powder refers to medicine with high purity and high content of active ingredients.It can ensure that the medicine will work efficiently since the high content and the efficiency of the medicine.

Adjustable

When using veterinary API powder,the dosage can be adjusted according to the actual situation of the farm and the needs of animals to achieve the best effect.

Less additives

There are a few additives in veterinary API powder, which will reduce the interference of additives on the role of veterinary medicines and reduce the burden on the animal.

Low cost

Veterinary API pure powder is usually in a low price, which can reduce the cost of breeding.

Types of Veterinary API

Kitasamycin

Kitasamycin is a macrolide antibacterial drug, its antibacterial spectrum is similar to that of erythromycin. Its mechanism of action is similar to that of erythromycin. Sensitive Gram-positive bacteria include Staphylococcus aureus (including penicillin-resistant Staphylococcus aureus), pneumococcus, streptococcus, Bacillus anthracis, Erysipelas suis, Listeria, Clostridium putrefaction, Clostridium emphysema etc. Sensitive Gram-negative bacteria include Haemophilus influenzae, Neisseria meningitidis, and Pasteurella. In addition, it also has a good effect on mycoplasma. The antibacterial effect on most Gram-positive bacteria is slightly inferior to that of erythromycin, and the antibacterial effect on mycoplasma is similar to that of Tylosin. The effect of Staphylococcus aureus is superior to erythromycin and tetracycline.Pharmacokinetics: It is well absorbed after oral administration and reaches the peak plasma concentration after 2 hours. It is widely distributed in major organs, among which the concentration in the liver, lung, kidney and muscle is relatively high, often exceeding the blood concentration. It is mainly excreted through the hepatobiliary system, with high concentrations in bile and feces. A small amount is excreted by the kidneys.

Avilamycin

Avilamycin has antibacterial effect mainly on Gram-positive bacteria. This product can improve the absorption of glucose in the intestinal tract of pigs and chickens, increase the production of volatile fatty acids and reduce the production of lactic acid.Therefore it will promote the growth of pigs and chickens. Avilamycin can effectively auxiliary control the occurrence and deterioration of diarrhea in weaned piglets caused by Escherichia coli clinically. Meanwhile, it can reduce the production of adherent pili on the surface of Escherichia coli. Since bacteria is short of surface-adhesive pili , which inhibits their adsorption on the intestinal mucosa and reduces intestinal damage. Thereby it control the occurrence of diarrhea and improve livestock growth performance indicators.This product is administered orally and hardly absorbed by the intestine, so there is very little residue in animal tissues.

Nosiheptide

The antibacterial mechanism of Nosiheptide is to inhibit the synthesis of bacterial protein, antibacterial at low concentration while bactericidal at high concentration. It has strong activity against Gram-positive bacteria, such as Staphylococcus and Clostridium, which are sensitive to it. It can promote growth and improve feed conversion rate for pigs and chickens. Mixed in feeding is rarely absorbed in the digestive tract of animals. There are few residues in animal products.

Maduramicin ammonium

Madumicin ammonium is a monovalent monoglycoside ionophore anticoccidial drug with a broad spectrum of anticoccidial. It is highly effective against Eimeria coccidioides such as poisonous, giant, tender, stacked, Brucelli, and metamorphosis in chickens. It is also effective against strains resistant to other polyether anticoccidiostats. Madumicin ammonium can interfere with the early stage of coccidia life cycle,that is, the sporozoite stage of coccidia development and the first generation of schizonts. Maduramicin ammonium not only inhibits the growth of coccidia, but also kills coccidia. When maduramicin ammonium is mixed with chickens (5mg/kg feed), the elimination half-life in liver, kidney, muscle,skin, fat and other tissues is about 24 hours.

Salinomycin

This product is a polyether ionophore anticoccidial drug. Its coccidial action mechanism is by interfering with the intracellular normal osmosis of K+,Na+, which allows a large amount of Na+ to enter into the cell. In order to balance the osmotic pressure, a large amount of water enters into the coccidial cells, causing swelling and death. It has effects on Eimeria coccidia such as poisonous, tender, giant, moderate, heap type, and Brucella, especially for giant and Eimeria brucei. It has obvious effect on sporozoites, first and second generation merozoites of chicken coccidia. In addition, salinomycin can also promote animal growth. Feeding 30-60 mg/kg medicine material to piglets which is less than 4 months old, and 15-30 mg/kg medicine to piglets aged 4-6 months can significantly increase body weight and improve feed utilization rate.Oral administration of salinomycin for chickens has little absorption in the gastrointestinal tract. The content in the liver, stomach and small intestine is relatively high while the content in other tissues is very small. Drugs that enters into the body are rapidly metabolized in the liver, secreted by the small intestine and excreted through the feces. The excretion within 48 hours after administration accounted for 94.6% of the administered dose, and over 97% within 72 hours.

Monensin sodium

This product is a monovalent ionophore broad-spectrum anticoccidiostat. It has a good killing effect on chicken poisoning, tenderness, giant, displacement, pile type, Eimeria brucei, etc. It is also effective for the dispersal of E.adenoeides and E.meleagridi and quail’s E.dispersa, Eimeria lytai, lamb Yashi and Eimeria azadi. The peak action period of monensin sodium is in the first two days of the life cycle of coccidia.It has inhibitory effect on sporozoites and first-generation schizonts. The drug effect is the best on the second day after coccidia infection. The mechanism of its coccidial action is to interfere with the normal penetration of K+ and Na+ in the coccidian cells, so that a large amount of Na+ and water enter into the cells, causing swelling and death. In addition, monensin sodium also has a strong antibacterial effect on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus, and Clostridium perfringens. It also can promote animal growth and development, increase body weight and improve feed utilization.

Nicarbazin

This product has a good control effect on various Eimeria in chickens, such as tender, fragile, poisonous, giant, heap, and Eimeria brucei. It mainly inhibits the growth and reproduction of schizonts in the second asexual proliferation stage. Its peak effect is on the 4th day after infection. It is mainly used for chicken and turkey coccidiosis. Coccidia are not easy to cause resistance to this product, so they are often used to replace the dosing regimen. In addition, for coccidia resistant to other anticoccidials, the use of nicarbazine is still effective in most cases. Nicarbazine has certain effects on egg quality and hatchability. This product can be absorbed by the digestive tract and widely distributed in body tissues and fluids. The recommended dose was fed to chickens for 11 days. After 2 days of drug withdrawal, residual drugs could still be detected in blood and edible tissues.

Decoquinate

Decoquinate is a quinoline anticoccidiostat, its main function is to hinder the development of coccidia sporozoites.Its peak period of action is the first day after coccidia infection. Since it can significantly inhibit the host body's immunity to coccidia, it should be applied continuously throughout the entire growth cycle of broilers. Coccidia are prone to develop drug resistance to decoquinate, so the drugs should be rotated regularly. Its anti-coccidial effect is related to the particle size of the drug. The finer the particle, the stronger the anti-coccidial effect. It should be made into particles with a diameter of about 1.8 μm for use.

Quinocetone

Quinocetone is a quinoxaline antibacterial drug, which has the effects of promoting growth and improving feed conversion rate.

Specification of Veterinary API

Veterinary API
Product name	Specification	Standard	Packing
Kitasamycin	≥80%	ES	25kg/Drum
Avilamycin	≥80%	ES	25kg/Drum
Nosiheptide	≥90%	CVP	25kg/Drum
Maduramicin ammonium	≥90%	CVP	25kg/Drum
Salinomycin	≥80%	ES	25kg/Drum
Monensin sodium	≥90%	CVP	25kg/Drum
Nicarbazin	≥98%	CVP	25kg/Drum
Decoquinate	≥98%	CVP	25kg/Drum
Quinocetone	≥98%	CVP	25kg/Drum

Application of Veterinary API

01/

Prevention

Prevent certain animal epidemics

02/

Treatment

Treat various diseases in animals

03/

Promote growth

Act as a feed additive to promote growth, improve the feed conversion rate and animal growth rate and reduce the production cost.

04/

Improve the palatability of feed

Improve the palatability of feed in order to improve the carcass quality and the taste of animal food, which can provide better animal products and reduce the food expenditure of consumers.

How to maintain Veterinary API?

1. Pay attention to mixture and incompatibility

Each Veterinary API has its own chemical ingredients.If mixed, their effect may reduce or increase.They would even be toxic. Therefore, when using drugs, we should pay attention to drug collocation and contraindications to avoid adverse reactions.

2. Pay attention to best opportunity for medication

Do not arbitrarily use drugs just based on the appearance when the disease of livestock and poultry has not been diagnosed. Its symptoms must be carefully observed, if necessary, the sample must be collected and sent to the relevant departments for laboratory diagnosis. Only on the basis of accurate diagnosis, can we get the due curative effect.

3. Pay attention to the dose

More dosage does not mean better effect.Many Veterinary APIs are used in large doses, which not only cause drug residue, but also cause livestock and poultry poisoning. We should pay attention to that the Veterinary API mixed into feed must be mixed evenly to prevent the poisoning. In addition, pay attention to the drug solubility and the amount of drinking water.We should also consider the solubility of the drug and the amount of livestock and poultry to ensure that livestock and poultry eat enough doses of drugs.

4. Pay attention to the course and the withdrawal period

To ensure that the course of medication time,the continuous use of time of Veterinary API must reach more than one course of treatment. In addition, Veterinary API has the regulation of drug rest period, so the marketing date of animals and their products must be fully considered when taking drugs to prevent excessive drug residues and avoid causing safety risks.

FAQ

Q: Is there any classification of veterinary API?

A: China implements classified management of veterinary APIs and divides veterinary APIs into veterinary prescription drugs and non-prescription drugs according to the safety and risk degree of veterinary drugs.

Q: How can enterprises ensure the quality of veterinary APIs?

A: In accordance with the Regulations on the Administration of Veterinary Drugs, China has formulated the Quality Management Practice for Veterinary Drug Production according to GMP(Good Manufacture Practice). The enterprise shall establish quality objectives that meet the quality management requirements of veterinary APIs and strictly implement the quality requirements in the whole process of production, quality control and product release, storage and sales of veterinary APIs.

Q: What standards should the raw materials used in the production of veterinary APIs and the packaging materials in direct contact with veterinary APIs meet?

A: The raw and auxiliary materials used in the production of veterinary APIs and the packaging materials in direct contact with veterinary APIs shall conform to the standards of veterinary APIs, drugs, packaging materials or other relevant standards. The inks used for direct printing on veterinary APIs shall meet the requirements of edible standards. The imported raw materials and auxiliary materials shall conform to the relevant state regulations on import administration.

Q: How can the production equipment avoid having adverse effects on the quality of veterinary APIs?

A: The production equipment shall avoid having adverse effects on the quality of veterinary APIs. The surface of the production equipment in direct contact with veterinary APIs shall be smooth, smooth, easy to clean and disinfect, and corrosion resistant. It shall not react with veterinary APIs, adsorb veterinary APIs or release substances into veterinary APIs to affect the product quality of veterinary products.

Q: How can enterprises promote the healthy development of the veterinary API industry?

A: Enterprises can devote themselves to the development and innovation of veterinary API and the improvement of production process to promote the healthy development of veterinary API industry.

Q: What should the records be kept for each batch of veterinary APIs?

A: Each batch of veterinary APIs shall have batch records, including batch production records, batch packaging records, batch inspection records, veterinary drug release review records, and electronic traceability code identification records, etc.

Q: What tests do veterinary API production enterprises need to go through to produce veterinary biological products?

A: Each batch of veterinary biological products produced by the veterinary drug manufacturer shall be examined and checked by the inspection institution and designated by the veterinary administrative department under the State Council before leaving the factory and carry out spot inspection when necessary. They shall not be sold without verification or failing the spot inspection.

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As one of the leading veterinary api manufacturers and suppliers in China, we warmly welcome you to buy high-grade veterinary api made in China here from our factory. All our products are with high quality and competitive price.

Salinomycin, Maduramicin api, Nosiheptide 4